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. 1997 Jun;16(2):144-53.
doi: 10.1038/ng0697-144.

A functional neo-centromere formed through activation of a latent human centromere and consisting of non-alpha-satellite DNA

D du Sart  1 , M R Cancilla, E Earle, J I Mao, R Saffery, K M Tainton, P Kalitsis, J Martyn, A E Barry, K H Choo
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A functional neo-centromere formed through activation of a latent human centromere and consisting of non-alpha-satellite DNA

D du Sart et al. Nat Genet. 1997 Jun.

Abstract

We recently described a human marker chromosome containing a functional neo-centromere that binds anti-centromere antibodies, but is devoid of centromeric alpha-satellite repeats and derived from a hitherto non-centromeric region of chromosome 10q25. Chromosome walking using cloned single-copy DNA from this region enabled us to identify the antibody-binding domain of this centromere. Extensive restriction mapping indicates that this domain has an identical genomic organization to the corresponding normal chromosomal region, suggesting a mechanism for the origin of this centromere through the activation of a latent centromere that exists within 10q25.

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  • Turning on the centromere.
    Choo KH. Choo KH. Nat Genet. 1998 Jan;18(1):3-4. doi: 10.1038/ng0198-3. Nat Genet. 1998. PMID: 9425884 No abstract available.

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