[The participation of cerebral hypoxia in the pathogenesis of neuroses (a new concept)]

Abstract

The data are presented concerning the state of vascular brain system during experimental neurosis in Wistar rats, the intricate cerebral hemodynamical disturbances, shifts in activity of the crucial enzymes of the mitochondrial respiratory chain, and activation of the lipid peroxidation processes. The positive results on treatment of the experimental and clinical neuroses with antioxidants which have antihypoxic properties are presented. Results on increase of resistance to stress in rats under the influence of negatively charged air ions with expressed antihypoxic are discussed. The general outline is given of the molecular neurochemical processes which accompany the development of neurotic diseases as well as of reversal of these processes due to the antioxidant therapy. The concept concerning the cerebral hypoxia in neuroses is based on the obtained evidence. This concept opens the principally novel pathogenetical approaches to treatment and prevention of these diseases.