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. 1997 Jun;41(6):1377-9.
doi: 10.1128/AAC.41.6.1377.

Pharmacodynamic properties of BAY 12-8039 on gram-positive and gram-negative organisms as demonstrated by studies of time-kill kinetics and postantibiotic effect

F J Boswell  1 , J M Andrews, R Wise
Affiliations

Pharmacodynamic properties of BAY 12-8039 on gram-positive and gram-negative organisms as demonstrated by studies of time-kill kinetics and postantibiotic effect

F J Boswell et al. Antimicrob Agents Chemother. 1997 Jun.

Abstract

Time-kill kinetics of BAY 12-8039 were studied at two inocula against three strains each of Bacteroides fragilis, Escherichia coli, Staphylococcus aureus, Haemophilus influenzae, and Streptococcus pyogenes. The postantibiotic effects of BAY 12-8039 were studied on three strains each of E. coli, S. aureus, H. influenzae, Streptococcus pyogenes, and Streptococcus pneumoniae. The pharmacodynamic data demonstrated that BAY 12-8039 has marked activity against gram-positive and gram-negative organisms (under both anaerobic and aerobic conditions) and anaerobes. BAY 12-8039 also exhibited a postantibiotic effect of >1 h for all strains except one E. coli strain.

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References

    1. J Antimicrob Chemother. 1989 Jan;23(1):53-8 - PubMed
    1. J Antimicrob Chemother. 1991 Sep;28(3):399-405 - PubMed
    1. Antimicrob Agents Chemother. 1995 Aug;39(8):1711-6 - PubMed
    1. Antimicrob Agents Chemother. 1995 Feb;39(2):507-12 - PubMed
    1. J Antimicrob Chemother. 1992 Nov;30(5):625-32 - PubMed

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