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. 1997 Jun;41(6):1392-5.
doi: 10.1128/AAC.41.6.1392.

Antifungal pharmacodynamic characteristics of fluconazole and amphotericin B tested against Candida albicans

M E Klepser  1 , E J Wolfe, R N Jones, C H Nightingale, M A Pfaller
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Antifungal pharmacodynamic characteristics of fluconazole and amphotericin B tested against Candida albicans

M E Klepser et al. Antimicrob Agents Chemother. 1997 Jun.

Abstract

Time-kill curves were determined for three isolates of Candida albicans tested against fluconazole and amphotericin B at multiples of the MIC. Fluconazole produced fungistatic activity, with concentration-related growth effects observed over a narrow range of concentrations. Amphotericin B exhibited fungicidal activity, with enhancement of activity over a broader range of concentrations.

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References

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