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Case Reports
. 1997 Jan;12(1):37-9.
doi: 10.1097/00004850-199701000-00005.

Reflux oesophagitis and clozapine

Affiliations
Case Reports

Reflux oesophagitis and clozapine

M K Laker et al. Int Clin Psychopharmacol. 1997 Jan.

Abstract

In a series of thirty-six patients treated with clozapine we report four cases who developed upper gastrointestinal symptoms suggestive of reflux oesophagitis within 6 weeks of starting this drug. Subsequent endoscopic examination revealed moderately severe erosive oesophagitis in three of them. Of these one had received treatment for a peptic ulcer in the past but the other two had no previous history of any upper gastrointestinal disorder. The pharmacology of clozapine in relation to gastro-oesophageal reflux is discussed.

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