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Comparative Study
. 1997 Jun;28(6):1195-7.
doi: 10.1161/01.str.28.6.1195.

Effect of PCO2 changes induced by head-upright tilt on transcranial Doppler recordings

S Cencetti  1 , G Bandinelli, A Lagi
Affiliations
Comparative Study

Effect of PCO2 changes induced by head-upright tilt on transcranial Doppler recordings

S Cencetti et al. Stroke. 1997 Jun.

Abstract

Background and purpose: Transcranial Doppler (TCD) monitoring of mean blood flow velocity (mV) during head-upright tilt can allow testing of cerebral autoregulation. Nonetheless, head-upright tilt can induce changes in the ventilation-perfusion relationship and/or respiratory activity that might influence TCD data.

Methods: Forty-eight healthy volunteers underwent monitoring of mV and end-tidal CO2 in the horizontal position and during head-upright tilt.

Results: Both mV and end-tidal CO2 significantly decreased in orthostasis (P < .01). Linear regression analysis showed a significant linkage between end-tidal CO2 and mV changes (r = .83, P < .01).

Conclusions: Changes in ventilation-perfusion ratio and in the respiratory pattern induced by head-upright tilt can significantly influence TCD data by determining a PCO2 decrease.

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