Review
doi: 10.1016/s0165-6147(97)01049-3.
Phosphodiesterase (PDE)4 inhibitors: anti-inflammatory drugs of the future?
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- PMID: 9184477
- DOI: 10.1016/s0165-6147(97)01049-3
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Review
Phosphodiesterase (PDE)4 inhibitors: anti-inflammatory drugs of the future?
Trends Pharmacol Sci.
1997 May.
Abstract
Phosphodiesterase type 4 (PDE4) plays a major role in modulating the activity of virtually all cells involved in the inflammatory process. Inhibitors of this enzyme family display impressive anti-inflammatory and disease-modifying effects in a variety of experimental models. In this review, Mauro Teixeira, Robert Gristwood, Nicola Cooper and Paul Hellewell examine the capacity of PDE4 inhibitors to exert anti-inflammatory actions in vivo and discuss the potential of this class of drugs to take their place as novel therapeutic agents for a variety of inflammatory diseases.
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