Cortical degeneration in progressive supranuclear palsy. A comparison with cortical-basal ganglionic degeneration
- PMID: 9184663
Cortical degeneration in progressive supranuclear palsy. A comparison with cortical-basal ganglionic degeneration
Abstract
We report 3 patients with progressive supranuclear palsy (PSP) who developed limb apraxia, focal dystonia, and arm levitation late in the course of the disease. Neuropathological examination revealed cortical degeneration in addition to the characteristic pathological findings of PSP. Semiquantitative comparative histological and immunohistological studies of the neocortex of these patients as well as 5 cases of classical PSP and 4 cases of cortical-basal ganglionic degeneration (CBGD) revealed a distinctive form of cortical degeneration in PSP. The cortical degeneration was often circumscribed and confined to premotor and motor cortex. It was characterized by neuronal loss and gliosis. Swollen neurons were only rarely observed in neocortex of PSP cases in contrast with CBGD, where they were abundant. Neuronal and glial tau as well as tau immunoreactive threads were seen in both PSP and CBGD, but were more abundant in CBGD. The appearance of tau reactive astrocytes also differed in both disorders; tufted astrocytes were seen exclusively in PSP, while typical annular astrocytic plaques were confined to CBGD. These observations indicate that cortical degeneration occurs in PSP and may be associated with atypical clinical manifestations that lead to diagnostic difficulties.
Similar articles
-
Distribution of astrocytic plaques in the corticobasal degeneration brain and comparison with tuft-shaped astrocytes in the progressive supranuclear palsy brain.Acta Neuropathol. 2003 Aug;106(2):143-9. doi: 10.1007/s00401-003-0711-4. Epub 2003 May 2. Acta Neuropathol. 2003. PMID: 12732936
-
Tau accumulation in astrocytes in progressive supranuclear palsy is a degenerative rather than a reactive process.Acta Neuropathol. 2002 Oct;104(4):398-402. doi: 10.1007/s00401-002-0569-x. Epub 2002 May 30. Acta Neuropathol. 2002. PMID: 12200627
-
A comparison of degeneration in motor thalamus and cortex between progressive supranuclear palsy and Parkinson's disease.Brain. 2005 Oct;128(Pt 10):2272-80. doi: 10.1093/brain/awh596. Epub 2005 Jul 13. Brain. 2005. PMID: 16014651
-
[Corticobasal degeneration and atypical progressive supranuclear palsy: their symptomatology, laboratory examination and differential diagnosis].Rinsho Shinkeigaku. 2004 Nov;44(11):982-5. Rinsho Shinkeigaku. 2004. PMID: 15651349 Review. Japanese.
-
[Neuropathological features in corticobasal degeneration and progressive supranuclear palsy].Rinsho Shinkeigaku. 2002 Nov;42(11):1155-7. Rinsho Shinkeigaku. 2002. PMID: 12784692 Review. Japanese.
Cited by
-
Corticobasal Degeneration.Curr Treat Options Neurol. 2003 Mar;5(2):161-168. doi: 10.1007/s11940-003-0006-z. Curr Treat Options Neurol. 2003. PMID: 12628064
-
Neurotrophic factors in Alzheimer's disease: role of axonal transport.Genes Brain Behav. 2008 Feb;7 Suppl 1(1):43-56. doi: 10.1111/j.1601-183X.2007.00378.x. Genes Brain Behav. 2008. PMID: 18184369 Free PMC article. Review.
-
Progressive supranuclear palsy: clinical features, pathophysiology and management.Drugs Aging. 2001;18(12):913-25. doi: 10.2165/00002512-200118120-00003. Drugs Aging. 2001. PMID: 11888346 Review.
-
Aberrant role of ALK in tau proteinopathy through autophagosomal dysregulation.Mol Psychiatry. 2021 Oct;26(10):5542-5556. doi: 10.1038/s41380-020-01003-y. Epub 2021 Jan 15. Mol Psychiatry. 2021. PMID: 33452442 Free PMC article.
-
Tau-positive glial inclusions in progressive supranuclear palsy, corticobasal degeneration and Pick's disease.Brain Pathol. 1999 Oct;9(4):663-79. doi: 10.1111/j.1750-3639.1999.tb00549.x. Brain Pathol. 1999. PMID: 10517506 Free PMC article. Review.
Publication types
MeSH terms
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical
Miscellaneous