Interleukin-8 level in maternal serum as a marker for screening of histological chorioamnionitis at term

Abstract

Objective: To establish a clinical method for immediate diagnosis of histological chorioamnionitis, by maternal blood sampling at term.

Method: The sera of 22 mothers with chorioamnionitis and 81 mothers without chorioamnionitis at term delivery were collected. The serum levels of cytokines including interleukin-1 alpha (IL-1 alpha), interleukin-1 beta (IL-1 beta), tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6) and interleukin-8 (IL-8) were titered and other conventional markers such as white blood cell and CRP were measured simultaneously. Chorioamnionitis was histopathologically confirmed after delivery.

Result: The sera of mothers with histological chorioamnionitis showed a significant increase in IL-8 titer, but not in those of other cytokines or conventional markers, compared with those without chorioamnionitis. A positive correlation was observed between maternal and cord serum IL-8 levels. Maternal IL-8 showed the highest predictive value for diagnosis of histological chorioamnionitis.

Conclusion: Measurement of maternal IL-8 is useful for rapid prenatal screening of histological chorioamnionitis at term.