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. 1977 Nov 25;198(4319):849-51.
doi: 10.1126/science.918669.

Benzodiazepine receptor: demonstration in the central nervous system

H Möhler, T Okada

Benzodiazepine receptor: demonstration in the central nervous system

H Möhler et al. Science. .

Abstract

Diazepam, a potent minor tranquilizer, binds with high affinity to a specific benzodiazepine receptor that occurs exclusively in the central nervous system. The receptor is mainly localized in the synaptic membrane fraction. Binding to the receptor is stereospecific. Competition for the receptor by various benzodiazepines closely parallels their pharmacological potency.

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