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. 1997 May 9;756(1-2):278-82.
doi: 10.1016/s0006-8993(97)00228-x.

Ethanol-induced c-Fos expression in rat lines selected for low and high alcohol consumption

T E Thiele  1 , G van Dijk, I L Bernstein
Affiliations

Ethanol-induced c-Fos expression in rat lines selected for low and high alcohol consumption

T E Thiele et al. Brain Res. .

Abstract

Selectively bred rat lines, developed to model genetic contributions to alcohol abuse, include the Indiana alcohol-preferring (P) and alcohol-nonpreferring (NP) lines, and the Alko-Alcohol (AA) and Alko-Nonalcohol (ANA) lines. Preferring and nonpreferring lines were compared in their response to intraperitoneal injection of either ethanol or isotonic saline using c-Fos expression as a marker of neuronal activity. Although line differences were noted in several brain regions, the principal finding was that alcohol-nonpreferring lines (NP and ANA) displayed greater c-Fos expression in the locus coeruleus (LC) relative to the alcohol-preferring lines (P and AA) following injection of 3.0 g ethanol/kg. These data point to the LC as an area which may play a role in the differences in voluntary ethanol consumption between rat lines genetically bred for low and high ethanol preference.

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