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. 1997 Jul;71(7):5361-5.
doi: 10.1128/JVI.71.7.5361-5365.1997.

Theiler's virus and Mengo virus induce cross-reactive cytotoxic T lymphocytes restricted to the same immunodominant VP2 epitope in C57BL/6 mice

S Dethlefs  1 , N Escriou, M Brahic, S van der Werf, E L Larsson-Sciard
Affiliations

Theiler's virus and Mengo virus induce cross-reactive cytotoxic T lymphocytes restricted to the same immunodominant VP2 epitope in C57BL/6 mice

S Dethlefs et al. J Virol. 1997 Jul.

Abstract

C57BL/6 mice develop a virus-specific cytotoxic T-lymphocyte (CTL) response after intraperitoneal inoculation with either the DA strain of Theiler's virus or Mengo virus, two members of the Cardiovirus genus. These CTLs contribute to viral clearance in the case of Theiler's virus but do not protect the mice from the fatal encephalomyelitis caused by Mengo virus. In this study we show that DA and Mengo virus-induced CTLs are cross-reactive. The cross-reactivity is due to a conserved, H-2Db-restricted epitope located between amino acid residues 122 and 130 of the VP2 capsid protein (VP2(122-130)). This epitope is immunodominant in C57BL/6 mice infected with Theiler's virus. The VP2(122-130) epitope, initially identified for Mengo virus, is the first CTL epitope described for Theiler's virus.

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References

    1. J Cell Physiol. 1965 Apr;65(2):229-35 - PubMed
    1. Virology. 1995 Dec 1;214(1):91-9 - PubMed
    1. J Immunol. 1981 Sep;127(3):1081-5 - PubMed
    1. Neurology. 1984 Aug;34(8):1117-9 - PubMed
    1. J Immunol. 1985 Aug;135(2):1408-14 - PubMed

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