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. 1977;33(5):270-2.
doi: 10.1111/j.1423-0410.1977.tb04473.x.

Possible linkage between the major histocompatibility complex and the immune response to factor VIII in classic haemophilia

D Frommel, J Y Muller, O Prou-Wartelle, J P Allain

Possible linkage between the major histocompatibility complex and the immune response to factor VIII in classic haemophilia

D Frommel et al. Vox Sang. 1977.

Abstract

The pattern of HLA segregation was analyzed in 10 sibships of haemophilia A patients, each of which included 1 or 2 haemophilic brothers with an antibody to factor VIII. The observed HLA distribution is suggestive of a linkage between the major histocompatibility complex and a gene responsible for immune response to isologous factor VIII.

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