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Review
. 1997 Apr;4(4):259-67.
doi: 10.1016/s1074-5521(97)90069-7.

Understanding enzymic catalysis: the importance of short, strong hydrogen bonds

J A Gerlt  1 , M M Kreevoy, W Cleland, P A Frey
Affiliations
Review

Understanding enzymic catalysis: the importance of short, strong hydrogen bonds

J A Gerlt et al. Chem Biol. 1997 Apr.

Abstract

We have proposed previously that short, strong hydrogen bonds exist in enzyme active sites and that they are important in explaining enzymic rate enhancements. Here, we defend this proposal and provide evidence for likely changes of hydrogen bond strengths during enzymic catalysis.

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