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Review
. 1997 May;4(5):329-34.
doi: 10.1016/s1074-5521(97)90123-x.

How do DNA repair proteins locate damaged bases in the genome?

G L Verdine  1 , S D Bruner
Affiliations
Review

How do DNA repair proteins locate damaged bases in the genome?

G L Verdine et al. Chem Biol. 1997 May.

Abstract

The genome is susceptible to the attack of reactive species that chemically modify the bases of DNA. If genetic information is to be transmitted faithfully to successive generations, it is essential that the genome be repaired. All organisms express proteins specifically dedicated to this task. But how do these proteins find the aberrant bases amongst the enormous number of normal ones?

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