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. 1997 Jun 27;276(5321):2037-9.
doi: 10.1126/science.276.5321.2037.

In vivo endoscopic optical biopsy with optical coherence tomography

G J Tearney  1 , M E Brezinski, B E Bouma, S A Boppart, C Pitris, J F Southern, J G Fujimoto
Affiliations

In vivo endoscopic optical biopsy with optical coherence tomography

G J Tearney et al. Science. .

Abstract

Current medical imaging technologies allow visualization of tissue anatomy in the human body at resolutions ranging from 100 micrometers to 1 millimeter. These technologies are generally not sensitive enough to detect early-stage tissue abnormalities associated with diseases such as cancer and atherosclerosis, which require micrometer-scale resolution. Here, optical coherence tomography was adapted to allow high-speed visualization of tissue in a living animal with a catheter-endoscope 1 millimeter in diameter. This method, referred to as "optical biopsy," was used to obtain cross-sectional images of the rabbit gastrointestinal and respiratory tracts at 10-micrometer resolution.

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  • Tissue optics.
    Benaron DA, Cheong WF, Stevenson DK. Benaron DA, et al. Science. 1997 Jun 27;276(5321):2002-3. doi: 10.1126/science.276.5321.2002. Science. 1997. PMID: 9221510 No abstract available.

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