Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1979 Aug;308(2):107-10.
doi: 10.1007/BF00499051.

PGI2 enhanced cAMP content in bovine coronary arteries in the presence of isobutylmethylxanthine

A Dembinska-Kiec, W Rücker, P S Schönhöfer

PGI2 enhanced cAMP content in bovine coronary arteries in the presence of isobutylmethylxanthine

A Dembinska-Kiec et al. Naunyn Schmiedebergs Arch Pharmacol. 1979 Aug.

Abstract

Incubation of bovine coronary artery (BCA) rings with isobutylmethylxanthine (IBMX) resulted in a time-dependent increase of cAMP content. This effect was blocked, when the rings were preincubated with indomethacine or 15-hydroperoxy-arachidonic acid for 5 min, indicating that the IBMX-induced increase in cAMP content may depend on endogenous PGI2 formation. PGE2 did not increase the cAMP content in BCA rings. Dipyridamole did not effect cAMP content, when used as a substitute for IBMX. It is suggested that PGI2 stimulates cAMP formation in arterial walls, but that this effect only becomes visible in the presence of a phosphodiesterase inhibitor.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Adv Cyclic Nucleotide Res. 1978;9:327-40 - PubMed
    1. Lancet. 1978 Jun 17;1(8077):1286-9 - PubMed
    1. Acta Pharmacol Toxicol (Copenh). 1973;32(5):321-36 - PubMed
    1. Naunyn Schmiedebergs Arch Pharmacol. 1979 Jan;306(1):101-3 - PubMed
    1. Ann N Y Acad Sci. 1976;275:321-9 - PubMed