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. 1997 Jul;17(7):4007-14.
doi: 10.1128/MCB.17.7.4007.

Characterization of a neuregulin-related gene, Don-1, that is highly expressed in restricted regions of the cerebellum and hippocampus

S J Busfield  1 , D A Michnick, T W Chickering, T L Revett, J Ma, E A Woolf, C A Comrack, B J Dussault, J Woolf, A D Goodearl, D P Gearing
Affiliations

Characterization of a neuregulin-related gene, Don-1, that is highly expressed in restricted regions of the cerebellum and hippocampus

S J Busfield et al. Mol Cell Biol. 1997 Jul.

Abstract

Members of the epidermal growth factor family of receptors have long been implicated in the pathogenesis of various tumors, and more recently, apparent roles in the developing heart and nervous system have been described. Numerous ligands that activate these receptors have been isolated. We report here on the cloning and initial characterization of a second ligand for the erbB family of receptors. This factor, which we have termed Don-1 (divergent of neuregulin 1), has structural similarity with the neuregulins. We have isolated four splice variants, two each from human and mouse, and have shown that they are capable of inducing tyrosine phosphorylation of erbB3, erbB4, and erbB2. In contrast to those of neuregulin, high levels of expression of Don-1 are restricted to the cerebellum and dentate gyrus in the adult brain and to fetal tissues.

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References

    1. J Biol Chem. 1994 Oct 7;269(40):25226-33 - PubMed
    1. Bioessays. 1993 Dec;15(12):815-24 - PubMed
    1. EMBO J. 1995 Sep 1;14(17):4267-75 - PubMed
    1. Cell. 1993 Mar 12;72(5):801-15 - PubMed
    1. J Clin Invest. 1995 Feb;95(2):842-51 - PubMed

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