Review
doi: 10.2170/jjphysiol.47.147.
Heterogeneity of corticotropin-releasing factor (CRF)
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- PMID: 9201544
- DOI: 10.2170/jjphysiol.47.147
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Review
Heterogeneity of corticotropin-releasing factor (CRF)
Jpn J Physiol.
1997 Apr.
Free article
Abstract
Although CRH is the major contributor to the physiological regulation of ACTH secretion, it must be recognized that a considerable degree of heterogeneity exists regarding the chemistry and biological activity of various CRF-active substances, some of which still remain to be fully clarified. The widespread extrahypothalamic sources and diverse extrapituitary actions of CRFs suggest that multiple CRF components must act in concert for the organism to cope with the environmental changes and stresses.
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