Intravenous drug compatibility: a challenge for the oncology nurse

Abstract

Purpose/objectives: To examine the cause(s) and types of IV incompatibilities that can occur in the oncology population, to present information on commonly used oncologic medications, to identify resources available to nurses, and to provide specific interventions designed to prevent incompatibilities in various oncology settings.

Data sources: Published articles, nursing and pharmacology textbooks.

Data synthesis: Many common oncologic medications are not compatible. A number of factors, including pH, drug additives, and cosolvents, may cause these incompatibilities. Incompatible reactions may be visually apparent or may occur on a molecular level.

Conclusions: A basic understanding of incompatibilities can minimize their occurrence. A variety of resources and interventions are available.

Implications for nursing practice: Incompatibilities can occur easily in a variety of oncology settings and can result in detrimental medical and financial outcomes. Nurses play an important role in preventing incompatibilities. They must be familiar with the medications they are administering and have access to compatibility information and resources.