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Comparative Study
. 1979 Sep;76(9):4395-9.
doi: 10.1073/pnas.76.9.4395.

Comparison of amino acid sequences of two human histocompatibility antigens, HLA-A2 and HLA-B7: location of putative alloantigenic sites

H T Orr, J A Lopez de Castro, P Parham, H L Ploegh, J L Strominger
Comparative Study

Comparison of amino acid sequences of two human histocompatibility antigens, HLA-A2 and HLA-B7: location of putative alloantigenic sites

H T Orr et al. Proc Natl Acad Sci U S A. 1979 Sep.

Abstract

The complete amino acid sequence for papain-solubilized HLA-B7 heavy chain is compared with the partial sequences of HLA-A2 and H-2Kb heavy chains. Although these molecules are highly conserved (i.e., 80% homology in comparing HLA-B7 with HLA-A2; 72% and 74% homology in comparing H-2Kb with HLA-A2 and HLA-B7, respectively), two stretches of greater variability are observed. These clusters of variability are discussed in terms of their possible involvement in the alloantigenic determinant(s) characteristic of these highly polymorphic membrane antigens.

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References

    1. Proc Natl Acad Sci U S A. 1976 Mar;73(3):910-4 - PubMed
    1. J Biol Chem. 1975 Jun 25;250(12):4512-9 - PubMed
    1. Biochemistry. 1975 Jul;14(13):3029-35 - PubMed
    1. J Biol Chem. 1975 Jan 25;250(2):557-64 - PubMed
    1. Science. 1977 Mar 25;195(4284):1293-300 - PubMed

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