Chemoenzymatic synthesis of glucose fatty esters
- PMID: 9203337
- DOI: 10.1016/s0008-6215(96)00340-0
Chemoenzymatic synthesis of glucose fatty esters
Abstract
D-Glucose fatty esters at C-6 were obtained by chemoenzymatic synthesis involving 1,2-O-cyclohexylidene-alpha-D-glucofuranose (1) followed by hydrolysis of the cyclohexylidene protecting group. The enzymatic esterification of 1 was performed with fatty acids of variable chain lengths (C8:0 to C18:0). The kinetic of the reaction was studied for each fatty acid and the structure of the octanoyl ester was determined by 1H and 13C NMR spectroscopy.