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Comparative Study
. 1997 Mar-Apr;60(2):42-4.

[The effect of heparin on the activity of the mono-oxygenase glucuronyl- and glutathione transferase systems in ultrasonic damage to the rat liver]

[Article in Russian]
K A Eĭsmont, M I Bushma, S S Mal'chik, T V Bushma, L F Legon'kova, I V Zverinskiĭ
  • PMID: 9206568
Comparative Study

[The effect of heparin on the activity of the mono-oxygenase glucuronyl- and glutathione transferase systems in ultrasonic damage to the rat liver]

[Article in Russian]
K A Eĭsmont et al. Eksp Klin Farmakol. 1997 Mar-Apr.

Abstract

Six days after local exposure of the rat liver (during operation) to ultrasound (2 W/cm2, 1 min), the cytochrome P-450 content in the microsomal fraction reduced, and the rate of NADPH oxidation, the NADPH cytochrome P-450 reductase activity, ethylmorphine demethylation and aniline hydroxylation decreased in 12 days the activity of NADPH-cytochrome b5 reductase and cytosol sulfobromophthalein-glutathione-S-transferase also reduced. Heparin administration (250 U/kg i.m. every other day 3 and 6 times) had an enzyme-activating effect (particularly in the late-term restoration period) in animals which had been exposed to ultrasound.

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