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. 1997 Jun;97(3):669-72.
doi: 10.1046/j.1365-2141.1997.1062924.x.

In vivo 'purging' of residual disease in CLL with Campath-1H

M J Dyer  1 , S M Kelsey, H J Mackay, E Emmett, P Thornton, G Hale, H Waldmann, A C Newland, D Catovsky
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In vivo 'purging' of residual disease in CLL with Campath-1H

M J Dyer et al. Br J Haematol. 1997 Jun.

Abstract

We assessed the role of human CD52 antibody (Campath-1H) in six patients with chronic lymphocytic leukaemia (CLL) treated to maximal response with purine analogues (fludarabine/deoxycoformycin) in whom persistent leukaemic infiltration of blood and bone marrow had precluded autologous stem cell transplantation. Five patients achieved haematological and histological complete remission following Campath-1H and one had minimal focal residual CLL in a trephine biopsy. Autologous transplantation was performed in two patients without complications and with rapid haemopoietic engraftment. Treatment with Campath-1H may be of value in eradicating residual disease in CLL and may facilitate high-dose therapy in young patients.

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