Randomized controlled trial of superovulation and insemination for infertility associated with minimal or mild endometriosis

Abstract

Objective: To evaluate the efficacy of superovulation and IUI versus no treatment for infertility associated with minimal or mild endometriosis.

Design: Randomized trial.

Setting(s): London Health Sciences Centre, University Campus, The University of Western Ontario, London, Ontario; and Royal Victoria Hospital, McGill University, Montreal, Quebec, Canada.

Patient(s): Three hundred eleven cycles in 103 couples in whom minimal or mild endometriosis was the sole identified subfertility factor.

Intervention(s): Superovulation with FSH and IUI.

Main outcome measure(s): Live birth.

Result(s): Live birth followed 14 of 127 (11%) superovulation and IUI cycles and 4 of 184 (2%) no-treatment cycles. The odds ratio was 5.6 (95% confidence interval 1.8 to 17.4) in favor of superovulation and IUI.

Conclusion(s): Treatment with superovulation and IUI was associated with superior outcome both by crude live-birth rates and proportional hazard analysis.