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Review
. 1997 Jul 1;7(7):R443-6.
doi: 10.1016/s0960-9822(06)00214-4.

Carcinogenesis: a balance between beta-catenin and APC

Affiliations
Review

Carcinogenesis: a balance between beta-catenin and APC

B M Gumbiner. Curr Biol. .

Abstract

A protein first identified by its association with cadherin cell adhesion molecules, beta-catenin, has been implicated in carcinogenesis. In a number of different types of cancer, signalling through beta-catenin is upregulated either by direct mutation of beta-catenin or loss of negative regulation by the APC tumor suppressor protein.

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