Carcinogenesis: a balance between beta-catenin and APC
- PMID: 9210368
- DOI: 10.1016/s0960-9822(06)00214-4
Carcinogenesis: a balance between beta-catenin and APC
Abstract
A protein first identified by its association with cadherin cell adhesion molecules, beta-catenin, has been implicated in carcinogenesis. In a number of different types of cancer, signalling through beta-catenin is upregulated either by direct mutation of beta-catenin or loss of negative regulation by the APC tumor suppressor protein.