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Comparative Study
. 1997 Jul;24(7):792-5.
doi: 10.1007/BF00879669.

DOTATOC: a powerful new tool for receptor-mediated radionuclide therapy

A Otte  1 , E Jermann, M Behe, M Goetze, H C Bucher, H W Roser, A Heppeler, J Mueller-Brand, H R Maecke
Affiliations
Comparative Study

DOTATOC: a powerful new tool for receptor-mediated radionuclide therapy

A Otte et al. Eur J Nucl Med. 1997 Jul.

Abstract

This study presents the first successful use of a peptidic vector, DOTATOC, labelled with the beta-emitting radioisotope yttrium-90, for the treatment of a patient with somatostatin receptor-positive abdominal metastases of a neuroendocrine carcinoma of unknown localization. Tumour response and symptomatic relief were achieved. In addition, the new substance DOTATOC was labelled with the diagnostic chemical analogue indium-111 and studied in three patients with histopathologically verified neuroendocrine abdominal tumours for its diagnostic sensitivity and compared with the commercially available OctreoScan. In all patients the kidney-to-tumour uptake ratio (in counts per pixel) was on average 1. 9-fold lower with 111In-DOTATOC than with OctreoScan. DOTATOC could be a potential new diagnostic and therapeutic agent in the management of neuroendocrine tumours.

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References

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