Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1977 Aug;52(8):638-41.
doi: 10.1136/adc.52.8.638.

Elimination of pethidine and bupivacaine in the newborn

L V Cooper, G W Stephen, P J Aggett

Elimination of pethidine and bupivacaine in the newborn

L V Cooper et al. Arch Dis Child. 1977 Aug.

Abstract

Pethidine or an epidural injection of bupivacaine are common forms of obstetric analgesia in Britain. Bupivacaine has been thought to have little effect on the fetus, but neurobehavioural studies have cast doubt on this. We therefore investigated the elimination of these drugs by babies in similar population groups. Bupivacaine was largely eliminated in just over one day, while pethidine required between 2 and 6 days. This could account for the persisting depression in babies whose mothers had received pethidine.

PubMed Disclaimer

References

    1. Am J Obstet Gynecol. 1964 Aug 15;89:1009-15 - PubMed
    1. Anaesthesia. 1977 Apr;32(4):324-7 - PubMed
    1. Acta Anaesthesiol Scand. 1976;20(2):141-6 - PubMed
    1. Anesthesiology. 1974 Feb;40(2):121-8 - PubMed
    1. J Pharm Pharmacol. 1967 Dec;19:Suppl:50S-52S - PubMed

LinkOut - more resources