Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1997 Apr;46(4):374-7.

[Hypercapnia induced reversible opening of the blood-brain barrier in experimental hyperbilirubinemia]

[Article in Spanish]
F Domínguez Ortega  1 , G González Azpeitia, M Cidrás Pidre, J Calvo Rosales
Affiliations
  • PMID: 9214231

[Hypercapnia induced reversible opening of the blood-brain barrier in experimental hyperbilirubinemia]

[Article in Spanish]
F Domínguez Ortega et al. An Esp Pediatr. 1997 Apr.

Abstract

Objective: The incidence of bilirubin encephalopathy in extremely ill neonates with low serum bilirubin is stimulating interest in factors that can modify the blood-brain barrier permeability and allow the passage of bilirubin-albumin macrocomplexes, which may be produced by hypercapnia.

Materials and methods: Without modifying the normal bilirubin-albumin affinity, we increased cerebral flow by two levels of hypercapnia (PCO2 67.1 and 101.9 mmHg), acquired by inhalation of CO2 enriched air (5 and 15%) and a decrease in pH (7.00 and 6.93).

Results: We demonstrate an increment in cerebral bilirubin deposition (control 2.43 +/- 0.54 mg/g versus 3.29 +/- 0.43 and 3.28 +/- 1.07, F = 4.80, p < 0.05) and I125 albumin (control 26.1 +/- 95.8 micrograms/g versus 364.4 +/- 156.1 and 430.8 +/- 122.4, F03.34, p < 0.05).

PubMed Disclaimer

Publication types

LinkOut - more resources