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Review
. 1997;43(2):135-7.
doi: 10.1002/(SICI)1097-0282(1997)43:2<135::AID-BIP6>3.0.CO;2-W.

Primary structure and biological activity of hemoglobin-related hypothalamic peptides

A A Galoyan  1
Affiliations
Review

Primary structure and biological activity of hemoglobin-related hypothalamic peptides

A A Galoyan. Biopolymers. 1997.

Abstract

Five individual fractions from bovine hypothalamic extract, displaying coronary constrictory activity, were isolated and sequenced. All of them belong to the hemorphin group of hemoglobin-derived peptides. These peptides bind calmodulin and activate calmodulin-dependent enzymes. The relationship of isolated peptides with other members of the hemorphin group is discussed. Several new fragments of hemoglobin alpha- and beta-chains with yet unidentified activity were obtained from the same source. Their amino acid sequences have considerable overlap with the known sequences of hemoglobin fragments isolated from other tissues.

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