Pancreatic insulo-acinar portal systems in humans, rats, and some other mammals: scanning electron microscopy of vascular casts

Abstract

Scanning electron microscopy of vascular casts showed that in the mouse, rat, and guinea pig, the pancreatic endocrine islets were frequently interlobular in position and emitted insulo-venous efferent vessels directly draining into veins. In these animals, the intralobular islets, located within the exocrine lobules, issued insulo-acinar portal vessels continuous with the lobular capillaries in addition to the insulo-venous efferent vessels. In humans, monkeys, cows, pigs, dogs, cats, and rabbits, essentially all islets in the pancreas were intralobular in location and emitted the insulo-acinar portal vessels only. In man and animals examined, especially in the murine species, many lobules lacked an islet, therefore the insular control over the exocrine pancreas seemed to be effected in more or less restricted areas of lobules.