Changes in immunologic variables (TNF-a, sCD8 and sCD4) during danazol treatment in patients with endometriosis
- PMID: 9222806
Changes in immunologic variables (TNF-a, sCD8 and sCD4) during danazol treatment in patients with endometriosis
Abstract
Design: The levels of TNF-a, sCD8, and sCD4 were measured in serum samples taken from 20 women. Blood samples for TNF-a, sCD8 and sCD4 levels were taken from 10 endometriotic women before treatment, during the last 15 days of a 6-month administration of danazol and 3 months after treatment. Blood samples were taken only once from 10 women without endometriosis (control group).
Results: TNF-a levels were higher in women with endometriosis before treatment compared to controls (P < .05). Administration of the drug significantly reduced the levels of TNF-a (P < .01) and sCD8 (P < .001).
Conclusion: This study indicates that danazol significantly reduces endometriosis-associated autoimmune abnormalities.
Similar articles
-
The possible anti-inflammatory role of circulating human leukocyte antigen levels in women with endometriosis after treatment with danazol and leuprorelin acetate depot.Mediators Inflamm. 2001 Apr;10(2):75-80. doi: 10.1080/09629350120054545. Mediators Inflamm. 2001. PMID: 11405553 Free PMC article.
-
Use of CA-125 in the diagnosis and management of endometriosis: influence of treatment with danazol.Int J Fertil Menopausal Stud. 1994 Mar-Apr;39(2):100-4. Int J Fertil Menopausal Stud. 1994. PMID: 8012438
-
Comparison of the effects of leuprorelin acetate and danazol treatments on serum CA-125 levels in women with endometriosis.Int J Fertil Womens Med. 2004 Mar-Apr;49(2):75-8. Int J Fertil Womens Med. 2004. PMID: 15188832 Clinical Trial.
-
[Clinical remission of colonic endometriosis with danazol: case report and bibliographic considerations].Acta Gastroenterol Latinoam. 1996;26(5):319-21. Acta Gastroenterol Latinoam. 1996. PMID: 9363272 Review. Spanish.
-
[Endometriosis treatment].Duodecim. 1994;110(9):903-8. Duodecim. 1994. PMID: 7588132 Review. Finnish. No abstract available.
Cited by
-
Peripheral biomarkers of endometriosis: a systematic review.Hum Reprod Update. 2010 Nov-Dec;16(6):651-74. doi: 10.1093/humupd/dmq009. Epub 2010 May 12. Hum Reprod Update. 2010. PMID: 20462942 Free PMC article.
-
The possible anti-inflammatory role of circulating human leukocyte antigen levels in women with endometriosis after treatment with danazol and leuprorelin acetate depot.Mediators Inflamm. 2001 Apr;10(2):75-80. doi: 10.1080/09629350120054545. Mediators Inflamm. 2001. PMID: 11405553 Free PMC article.
-
Genistein modulates the estrogen receptor and suppresses angiogenesis and inflammation in the murine model of peritoneal endometriosis.J Tradit Complement Med. 2017 Apr 25;8(2):278-281. doi: 10.1016/j.jtcme.2017.03.002. eCollection 2018 Apr. J Tradit Complement Med. 2017. PMID: 29736382 Free PMC article.
-
Blood biomarkers for the non-invasive diagnosis of endometriosis.Cochrane Database Syst Rev. 2016 May 1;2016(5):CD012179. doi: 10.1002/14651858.CD012179. Cochrane Database Syst Rev. 2016. PMID: 27132058 Free PMC article.
-
Immune interactions in endometriosis.Expert Rev Clin Immunol. 2011 Sep;7(5):611-26. doi: 10.1586/eci.11.53. Expert Rev Clin Immunol. 2011. PMID: 21895474 Free PMC article.
MeSH terms
Substances
LinkOut - more resources
Other Literature Sources
Medical