Effect of two anti-estrogens, clomiphene citrate and tamoxifen, on cervical mucus and sperm-cervical mucus interaction
- PMID: 9222807
Effect of two anti-estrogens, clomiphene citrate and tamoxifen, on cervical mucus and sperm-cervical mucus interaction
Abstract
Objective: To compare the effect of two ovulation-inducing agents, clomiphene citrate and tamoxifen, on cervical mucus and sperm-cervical mucus interaction.
Subjects and setting: Forty couples with unexplained infertility attending infertility clinic.
Methods: Cervical mucus scoring and postcoital test done using the Moghissi system in a spontaneous cycle (control cycle) and with clomiphene citrate or tamoxifen (study cycles).
Results: Clomiphene citrate significantly decreased cervical mucus production, whereas tamoxifen significantly improved the total score.
Conclusion: Tamoxifen is a better drug than clomiphene for ovulation induction in women with poor cervical mucus quality.
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