Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comparative Study
. 1997 Jul;28(3):388-404.
doi: 10.1002/(sici)1097-0134(199707)28:3<388::aid-prot9>3.0.co;2-8.

Automated multiple analysis of protein structures: application to homology modeling of cytochromes P450

P Jean  1 , J Pothier, P M Dansette, D Mansuy, A Viari
Affiliations
Comparative Study

Automated multiple analysis of protein structures: application to homology modeling of cytochromes P450

P Jean et al. Proteins. 1997 Jul.

Abstract

A computational strategy for homology modeling, using several protein structures comparison, is described. This strategy implies a formalized definition of structural blocks common to several protein structures, a new program to compare these structures simultaneously, and the use of consensus matrices to improve sequence alignment between the structurally known and target proteins. Applying this method to cytochromes P450 led to the definition of 15 substructures common to P450cam, P450BM3, and P450terp, and to proposing a 3D model of P450eryF.

PubMed Disclaimer

Publication types

Substances

Associated data

LinkOut - more resources