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. 1997 Aug;71(8):6179-82.
doi: 10.1128/JVI.71.8.6179-6182.1997.

Specific infection and destruction of dopaminergic neurons in the substantia nigra by Theiler's virus

K R Oliver  1 , P Brennan, J K Fazakerley
Affiliations

Specific infection and destruction of dopaminergic neurons in the substantia nigra by Theiler's virus

K R Oliver et al. J Virol. 1997 Aug.

Abstract

Theiler's murine encephalomyelitis virus was stereotaxically inoculated unilaterally into the substantia nigra of the mouse brain. Virus specifically infected tyrosine hydroxylase-positive neurons and spread rostrocaudally throughout this subpopulation of neurons, resulting in impaired function and degeneration of the substantia nigra. The spread of the virus to other areas of the brain was minimal and rare.

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References

    1. Neuropatol Pol. 1966 Jul-Dec;4(3):449-56 - PubMed
    1. Arch Neurol. 1965 Mar;12:227-39 - PubMed
    1. J Neurol Sci. 1975 Sep;26(1):49-60 - PubMed
    1. Brain Res. 1979 Jun 22;169(2):401-5 - PubMed
    1. Pharmacol Biochem Behav. 1980 Jan;12(1):61-6 - PubMed

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