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Review
. 1997 Mar;24(1-2):125-31.
doi: 10.1023/a:1006803512761.

Eubacterial proteasomes

A Lupas  1 , F Zühl, T Tamura, S Wolf, I Nagy, R De Mot, W Baumeister
Affiliations
Review

Eubacterial proteasomes

A Lupas et al. Mol Biol Rep. 1997 Mar.

Abstract

Proteasomes are large, multisubunit proteases with highly conserved structures. The 26S proteasome of eukaryotes is an ATP-dependent enzyme of about 2 MDa, which acts as the central protease of the ubiquitin-dependent pathway of protein degradation. The core of the 26S complex is formed by the 20S proteasome, an ATP-independent, barrel-shaped protease of about 700 kDa, which has also been detected in archaebacteria and, more recently, in eubacteria. Currently, the distribution of 20S proteasomes in eubacteria appears limited to the actinomycetes, while most other eubacteria contain a related complex of simpler structure.

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