[Effect of withdrawal of phenazepam and nicotinamide on the status of the system of reception of benzodiazepines and NAD]

Abstract

Comparative investigations in reception of NAD, benzodiazepines and GABA by synaptic membranes under a single and multiple administration of phenazepam and nicotinamide to animals as well as after withdrawal of long-term administration of these drugs have been carried out. The both drugs activate GABA-inhibiting system of synaptic membranes. Both the sections of specific binding of benzodiazepines and of NAD take part in realization of "cancellation" syndrome. Chronic administration of phenazepam and nicotinamide results in the change of coupling in GABA-benzodiazepine receptor complex. After the withdrawal of chronic administration of nicotinamide the function of GABA-benzodiazepine receptor complex is normalized more quickly.