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. 1977 Dec;22(6):912-6.
doi: 10.1002/cpt1977226912.

Effectiveness of prednisolone during phenytoin therapy

L B Petereit, A W Meikle

Effectiveness of prednisolone during phenytoin therapy

L B Petereit et al. Clin Pharmacol Ther. 1977 Dec.

Abstract

The effects of diphenylhydantoin (DPH) on the clearance of prednisolone from plasma, its bioavailability, and its biologic effectiveness were studied in 5 persons before and after daily DPH therapy for more than 3 wek. DPH decreased the mean half-time of disappearance of prednisolone from plasma by 45% and increased its metabolic clearance rate by an average of 77%. The gastrointestinal absorption of prednisolone and its first-pass clearance through splanchnic tissues were not significantly altered by DPH. The mean oral midnight dose of prednisolone required to suppress the 8 A.M. plasma level of cortisol to 5 microgram/dl was doubled following treatment of DPH. The increment in dose of prednisolone varied from 58% to 260% in the five individuals.

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