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. 1977 Nov 15;33(11):1495-7.
doi: 10.1007/BF01918830.

Role of the pituitary in cyproheptadine-induced pancreatic beta-cell toxicity

K L Hintze, A B Grow, L J Fischer

Role of the pituitary in cyproheptadine-induced pancreatic beta-cell toxicity

K L Hintze et al. Experientia. .

Abstract

Hypophysectomized rats given cyproheptadine (40 mg/kg) for 10 days exhibited a loss of pancreatic immunoreactive insulin and ultrastructural changes in the cytoplasm of beta-cells. Sham-operated animals given cyproheptadine showed identical changes in pancreatic beta-cells except that cytoplasmic involvement progressed to the formation of large vacuoles. The pituitary is not directly involved with the cyproheptadine-induced depletion of pancreatic insulin but plays a role in the formation of large cytoplasmic vacuoles.

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