In vivo imaging of fatty acid incorporation into brain to examine signal transduction and neuroplasticity involving phospholipids
- PMID: 9237449
- DOI: 10.1111/j.1749-6632.1997.tb46189.x
In vivo imaging of fatty acid incorporation into brain to examine signal transduction and neuroplasticity involving phospholipids
Abstract
An in vivo method is presented that allows quantification and imaging of fatty acid incorporation into different brain phospholipids in relation to membrane synthesis, neuroplasticity, and signal transduction. The method can be used with positron emission tomography, and may help to evaluate brain phospholipid metabolism in humans with brain tumors, neurodegenerative disease, cerebral ischemia or trauma, or neurotoxic effects of drugs or other agents.
Similar articles
-
In vivo fatty acid incorporation into brain phospholipids in relation to signal transduction and membrane remodeling.Neurochem Res. 1999 Nov;24(11):1403-15. doi: 10.1023/a:1022584707352. Neurochem Res. 1999. PMID: 10555781 Review.
-
In vivo fatty acid incorporation into brain phosholipids in relation to plasma availability, signal transduction and membrane remodeling.J Mol Neurosci. 2001 Apr-Jun;16(2-3):243-61; discussion 279-84. doi: 10.1385/JMN:16:2-3:243. J Mol Neurosci. 2001. PMID: 11478380 Review.
-
A quantitative method for measuring regional in vivo fatty-acid incorporation into and turnover within brain phospholipids: review and critical analysis.Brain Res Brain Res Rev. 1992 Sep-Dec;17(3):187-214. doi: 10.1016/0165-0173(92)90016-f. Brain Res Brain Res Rev. 1992. PMID: 1467810 Review.
-
In vivo labeling of brain phospholipids by long-chain fatty acids: relation to turnover and function.Lipids. 1996 Mar;31 Suppl:S97-101. doi: 10.1007/BF02637059. Lipids. 1996. PMID: 8729102
-
Energy requirements for two aspects of phospholipid metabolism in mammalian brain.Biochem J. 1998 Oct 15;335 ( Pt 2)(Pt 2):313-8. doi: 10.1042/bj3350313. Biochem J. 1998. PMID: 9761729 Free PMC article.
Cited by
-
A model for fatty acid transport into the brain.J Mol Neurosci. 2007 Sep;33(1):12-7. doi: 10.1007/s12031-007-0050-3. J Mol Neurosci. 2007. PMID: 17901540 Review.
-
In vivo fatty acid incorporation into brain phospholipids in relation to signal transduction and membrane remodeling.Neurochem Res. 1999 Nov;24(11):1403-15. doi: 10.1023/a:1022584707352. Neurochem Res. 1999. PMID: 10555781 Review.
-
Hypothalamic Fatty Acids and Ketone Bodies Sensing and Role of FAT/CD36 in the Regulation of Food Intake.Front Physiol. 2019 Aug 14;10:1036. doi: 10.3389/fphys.2019.01036. eCollection 2019. Front Physiol. 2019. PMID: 31474875 Free PMC article. Review.
-
Imaging incorporation of circulating docosahexaenoic acid into the human brain using positron emission tomography.J Lipid Res. 2009 Jul;50(7):1259-68. doi: 10.1194/jlr.M800530-JLR200. Epub 2008 Dec 26. J Lipid Res. 2009. PMID: 19112173 Free PMC article.
-
Reduced palmitate turnover in brain phospholipids of pentobarbital-anesthetized rats.Neurochem Res. 1999 Jul;24(7):833-41. doi: 10.1023/a:1020997728511. Neurochem Res. 1999. PMID: 10403622
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Medical