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. 1997 Jul;26(1):29-31.
doi: 10.1016/s0741-5214(97)70143-5.

Detection of Chlamydia pneumoniae in atherosclerotic plaques in the walls of arteries of lower extremities from patients undergoing bypass operation for arterial obstruction

C C Kuo  1 , A S Coulson, L A Campbell, A L Cappuccio, R D Lawrence, S P Wang, J T Grayston
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Free article

Detection of Chlamydia pneumoniae in atherosclerotic plaques in the walls of arteries of lower extremities from patients undergoing bypass operation for arterial obstruction

C C Kuo et al. J Vasc Surg. 1997 Jul.
Free article

Abstract

Purpose: To study surgically excised vascular tissue from lower extremities for the presence of Chlamydia pneumoniae, to extend the previously described association of the organism with atherosclerosis.

Methods: Arterial biopsy specimens obtained from femoral and popliteal arteries during bypass operation for claudication were examined by immunocytochemical analysis and polymerase chain reaction for the presence of organisms.

Results: C. pneumoniae was detected in atherosclerotic plaques by either method in either artery of 11 of 23 patients (48%). Eight of 21 popliteal and three of 18 femoral arteries had positive results.

Conclusions: Detection of C. pneumoniae in peripheral arteries indicates that the organism is widespread in atherosclerosis of the vascular system.

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