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. 1977;22(5):321-8.
doi: 10.1007/BF02877666.

Strain improvement in Streptomyces galilaeus, a producer of anthracycline antibiotics galirubins

E Královocová, M Blumauerová, Z Vanĕk

Strain improvement in Streptomyces galilaeus, a producer of anthracycline antibiotics galirubins

E Královocová et al. Folia Microbiol (Praha). 1977.

Abstract

The production of epsilon-pyrromycinone glycosides in Streptomyces galilaeus increased 12-fold, with respect to the wild strain, as a result of a sequential procedure including both natural selection and treatment with mutagens (nitrous acid, UV light and gamma-irradiation). Nitrous acid exhibited the highest mutagenic effect, both in increasing the productivity and in inducing blocked mutants. A mutant strain blocked in the biosynthesis of glycosides and accumulating free epsilon-pyrromycinone as the principal metabolite was obtained.

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