Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1997 Jul 7;411(1):71-6.
doi: 10.1016/s0014-5793(97)00607-8.

The effect of some peptides from the hibernating brain on Ca2+ current in cardiac cells and on the activity of septal neurons

Y M Kokoz  1 , K I Zenchenko, A E Alekseev, A F Korystova, D A Lankina, R H Ziganshin, I I Mikhaleva, V T Ivanov
Affiliations
Free article

The effect of some peptides from the hibernating brain on Ca2+ current in cardiac cells and on the activity of septal neurons

Y M Kokoz et al. FEBS Lett. .
Free article

Abstract

The effects of the peptides TSKYR and DY isolated from the brain of hibernating ground squirrels on Ca2+ current were studied. TSKYR activated Ca2+ current in frog auricle fibers and in single cells from frog ventricle whereas DY blocked Ca2+ current in both preparations. In isolated rat and ground squirrel cardiocytes, TSKYR had no effect on Ca2+ current, and DY increased it. In brain slices of rat, DY blocked the activity of medial septal neurons. TSKYR increased activity of septal neurons at the initial phase, which was followed by decrease of neuronal activity.

PubMed Disclaimer

Publication types

MeSH terms

LinkOut - more resources