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. 1997 Aug;73(2):1110-7.
doi: 10.1016/S0006-3495(97)78143-8.

High-gain, low-noise amplification in olfactory transduction

S J Kleene  1
Affiliations

High-gain, low-noise amplification in olfactory transduction

S J Kleene. Biophys J. 1997 Aug.

Abstract

It is desirable that sensory systems use high-gain, low-noise amplification to convert weak stimuli into detectable signals. Here it is shown that a pair of receptor currents underlying vertebrate olfactory transduction constitutes such a scheme. The primary receptor current is an influx of Na+ and Ca2+ through cAMP-gated channels in the olfactory cilia. External divalent cations improve the signal-to-noise properties of this current, reducing the mean current and the current variance. As Ca2+ enters the cilium, it gates Cl- channels, activating a secondary depolarizing receptor current. This current amplifies the primary current, but introduces little additional noise. The system of two currents plus divalent cations in the mucus produces a large receptor current with very low noise.

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