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. 1997 Aug 1;153(1):129-34.
doi: 10.1111/j.1574-6968.1997.tb10473.x.

Identification and characterization of the gyrB gene from Treponema pallidum subsp. pallidum

L V Stamm  1 , S R Greene, N Y Barnes
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Identification and characterization of the gyrB gene from Treponema pallidum subsp. pallidum

L V Stamm et al. FEMS Microbiol Lett. .

Abstract

The nucleotide sequence of a DNA gyrase B subunit gene (gyrB) from Treponema pallidum has been determined. Southern blot analysis of T. pallidum chromosomal DNA indicated that this gene is present as a single copy. The organization of genes flanking the gyrB gene is unique in comparison to that of other bacteria. The gyrB gene encodes a 637 amino acid protein whose deduced sequence has a high degree of homology with type-II topoisomerase ATPase subunits (GyrB and ParE). Five type-II topoisomerase motifs, an ATP-binding site (Walker A), and amino acid residues that putatively interact with ATP, are highly conserved in the T. pallidum GyrB protein.

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