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Review
. 1997 Jul;22(7):267-72.
doi: 10.1016/s0968-0004(97)01061-x.

Phosphoinositide 3-kinases: a conserved family of signal transducers

B Vanhaesebroeck  1 , S J Leevers, G Panayotou, M D Waterfield
Affiliations
Review

Phosphoinositide 3-kinases: a conserved family of signal transducers

B Vanhaesebroeck et al. Trends Biochem Sci. 1997 Jul.

Abstract

Phosphoinositide 3-kinases (PI3Ks) generate lipids that are implicated in receptor-stimulated signalling and in the regulation of membrane traffic. Several distinct classes of PI3Ks have now been identified that have been conserved throughout eukaryotic evolution. Potential signalling pathways downstream of PI3Ks have been elucidated and PI3K function is now being characterised in several model organisms.

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