Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1997 Jul;131(1 Pt 1):147-50.
doi: 10.1016/s0022-3476(97)70139-2.

Defective antigen-induced lymphocyte proliferation in the X-linked hyper-IgM syndrome

R Ameratunga  1 , H M Lederman, K E Sullivan, H D Ochs, K Seyama, J K French, R Prestidge, J Marbrook, W C Fanslow, J A Winkelstein
Affiliations
Free article

Defective antigen-induced lymphocyte proliferation in the X-linked hyper-IgM syndrome

R Ameratunga et al. J Pediatr. 1997 Jul.
Free article

Abstract

We examined T-cell proliferation in five patients with X-linked hyper-IgM syndrome (XHIM), using a panel of antigens and lectins. All patients had impaired antigen-induced proliferation, whereas their lectin responses were normal. Thus, in addition to severely depressed antibody responses, patients with XHIM have a defect in antigen-specific T-cell proliferation, which may explain their susceptibility to pathogens such as Pneumocystis carinii.

PubMed Disclaimer

Comment in

Publication types

MeSH terms

LinkOut - more resources