Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Clinical Trial
. 1997 Aug;18(4):358-77.
doi: 10.1016/s0197-2456(97)00012-3.

Design of the Trial of Org 10172 in Acute Stroke Treatment (TOAST)

H P Adams Jr  1 , R F Woolson, W R Clarke, P H Davis, B H Bendixen, B B Love, P A Wasek, K J Grimsman
Affiliations
Clinical Trial

Design of the Trial of Org 10172 in Acute Stroke Treatment (TOAST)

H P Adams Jr et al. Control Clin Trials. 1997 Aug.

Abstract

TOAST is a multicenter, randomized, placebo-controlled clinical trial testing the usefulness of a new antithrombotic drug in improving the outcome of persons with acute ischemic stroke. Until recently, no clinical trial testing a treatment for ischemic stroke had demonstrated efficacy in outcome. Design problems of previously conducted trials with inconclusive results may partly explain their failures. During the design of TOAST, the investigators addressed several issues so the trial could test the treatment accurately. We report the strategies used in designing, implementing, and coordinating the trial.

PubMed Disclaimer

Publication types

MeSH terms

LinkOut - more resources