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. 1997 Aug;41(8):1775-7.
doi: 10.1128/AAC.41.8.1775.

Treatment of murine disseminated candidiasis with L-743,872

J R Graybill  1 , L K Najvar, M F Luther, A W Fothergill
Affiliations

Treatment of murine disseminated candidiasis with L-743,872

J R Graybill et al. Antimicrob Agents Chemother. 1997 Aug.

Abstract

L-743,872 (M991), which is a pneumocandin derivative, was evaluated in a mouse model of disseminated candidiasis caused by a fluconazole-resistant isolate of Candida albicans. In immunocompetent mice M991 prolonged survival at doses as low as 0.0125 mg/kg of body weight per day. In neutropenic mice 0.05 mg/kg was the lowest effective dose. M991 is a very potent drug for treatment of disseminated candidiasis.

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References

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