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Comparative Study
. 1997 Aug;41(8):1830-1.
doi: 10.1128/AAC.41.8.1830.

Comparative in vitro activities of carbapenem L-749,345 and other antimicrobials against multiresistant gram-negative clinical pathogens

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Comparative Study

Comparative in vitro activities of carbapenem L-749,345 and other antimicrobials against multiresistant gram-negative clinical pathogens

G Jacoby et al. Antimicrob Agents Chemother. 1997 Aug.

Abstract

Carbapenems L-749,345 and imipenem had the lowest MICs at which 90% of isolates were inhibited (0.5 microg/ml) of 14 antimicrobial agents tested against 76 multiresistant gram-negative clinical isolates with TEM- or SHV-type extended-spectrum beta-lactamases and chromosomal or plasmid-determined AmpC beta-lactamases, but the MIC of L-749,345 for one isolate of Klebsiella pneumoniae was 16 microg/ml.

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References

    1. J Clin Microbiol. 1996 Apr;34(4):908-11 - PubMed
    1. Antimicrob Agents Chemother. 1995 Jun;39(6):1211-33 - PubMed

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